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Isolated trigonocephaly

2 OMIM references -
2 associated genes
7 signs/symptoms

COMMON GENES: 1

Congenital diaphragmatic hernia

4 OMIM references -
3 associated genes
1 sign/symptom

Isolated trigonocephaly

Congenital diaphragmatic hernia

FGFR1	(UniProt - OMIM)		FREM1	(UniProt - OMIM)
FREM1	(UniProt - OMIM)		GATA6	(UniProt - OMIM)
			ZFPM2	(UniProt - OMIM)


COMMON GENES	FREM1

Citations in the biomedical literature:

Isolated trigonocephaly		Congenital diaphragmatic hernia
	Synonym(s): - Non-syndromic metopic craniosynostosis		Synonym(s): - CDH - Diaphragmatic agenesia

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare abdominal surgical disease - Rare developmental defect during embryogenesis - Rare respiratory disease - Rare surgical thoracic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: multigenic/multifactorial

	External references: 2 OMIM references - No MeSH references		External references: 4 OMIM references - 1 MeSH reference: C538080

Isolated trigonocephaly		Congenital diaphragmatic hernia
	Very frequent - Autosomal dominant inheritance - Trigonocephaly Frequent - Broad nasal root - Hypotelorism - Prominent supraorbital ridge - Synophris / synophrys Occasional - Omphalocele / exomphalos		Very frequent - Diaphragmatic hernia / defect / agenesis